In the year Universal Century 0079, humans have colonized the area of space lying in between the Earth and the moon. However, the ambitious Zabi family, rulers of the Duchy of Zeon, the grouping of colonies furthest from the earth, has sparked a war.

After surviving attacks by Zeon's Char Aznable and Garma Zabi, the crew of Federation warship White Base and its mobile suits must battle Zeon forces through Asia, Europe, and the Atlantic Ocean if they are to reach Earth Federation's headquarters alive. During that process, many of its crewmembers must overcome their fears, losses, immaturities, and insecurities in order to persevere.

A secret military project endangers Neo-Tokyo when it turns a biker gang member into a rampaging psychic psychopath that only two teenagers and a group of psychics can stop.

In the year 2029, the barriers of our world have been broken down by the net and by cybernetics, but this brings new vulnerability to humans in the form of brain-hacking. When a highly-wanted hacker known as 'The Puppetmaster' begins involving them in politics, Section 9, a group of cybernetically enhanced cops, are called in to investigate and stop the Puppetmaster.

SEELE orders an all-out attack on NERV, aiming to destroy the Evas before Gendo can advance his own plans for the Human Instrumentality Project. Shinji is pushed to the limits of his sanity as he is forced to decide the fate of humanity.

In UC 0093, the Federation has recovered from its defeat and has created a new anti-colonial special forces unit to deal with rebel forces: Londo Bell. Elsewhere in space, Char Aznable reappears out of self-imposed hiding with a declaration that he now commands his own Neo-Zeon movement, and intends to force the emigration of Earth's inhabitants to space by bringing about an apocalypse.

Twelve years after Char's rebellion, Hathaway Noa leads an insurgency against Earth Federation, but meeting an enemy officer and a mysterious woman alters his fate.

In C.E.75, the fighting still continues. There are independence movements, and aggression by Blue Cosmos... In order to calm the situation, a global peace monitoring agency called COMPASS is established, with Lacus as its first president. As members of COMPASS, Kira and his comrades intervene into various regional battles. Then a newly established nation called Foundation proposes a joint operation against a Blue Cosmos stronghold.

Universal Century 0068, Side 3 - The Autonomous Republic of Munzo. Zeon Zum Deikun attempts to declare complete independence of Munzo from the Earth Federation Government, while he preaches the evolutionary potential of humans who have advanced into outer space. Deikun however suddenly falls to his death in the middle of his speech at parliament. Upon Deikun's death, Jimba Ral spreads word of a House of Zabi conspiracy - but despite such efforts the power and sphere of influence of House of Zabi, led by Degwin Sodo Zabi, only seem to escalate. While we witness for the first time the untold convulsions of Universal Century history, Casval and Artesia, just bereaved of their father, must face destinies which will be just as tumultuous as the very era itself.

On January 23, U.C. 0079, a decisive battle between Zeon and the Earth Federation begins at Side 5, or Loum. Though the Zeon forces are overwhelmingly outnumbered, their secret plan suddenly turns the tide of battle as they deploy a special assault regiment made up of humanoid mobile suit weapons, winning them a huge victory. Char Aznable of the Zeon forces produces particularly impressive results in his red mobile suit “Zaku II”, earning a promotion to Lieutenant Commander and the nickname "Red Comet." After the Battle of Loum, the Earth Federation Forces initiate Operation V to fight back against Zeon. At Side 7, young Amuro Ray is indirectly involved as he takes action to uncover the secret of the new weapon "Gundam." Meanwhile, as high officials of the Earth Federation and Zeon forces meet in Antarctica for early peace negotiations, a certain speech is broadcast from Luna II throughout the world...